Inflammation. Disc Degeneration. There is a relationship.
Inflammation is the body’s response to damaging
stimuli (injury, pathogens, metabolic stress – a disc herniation pushing
on a nerve!) as it tries to repair itself
before the harm was achieved. Cox Chiropractic Medicine Inc is never
shocked at how the body takes care of itself!
Cox Chiropractic Medicine Inc sees its Fort Wayne chiropractic care as the body’s partner in healing particularly
when spine pain is an issue. Chiropractic care uses
many tools like spinal manipulation, exercise, and nutrition to take care of
the body. Melatonin is one nutritional tool that is showing value
by interrupting the inflammatory process
related disc herniation that brings about pain relief: back, neck, spine-related.
DISC DEGENERATION AND INFLAMMATION AND 'AUTOPHAGY'
Inflammatory markers interleukin-1β (IL-1β), interleukin-6
(IL-6) and tumor necrosis factor-α (TNF-α) are linked to intervertebral disc degeneration. (1) IL-1 β in fact promotes
itself, its own expression, by upregulating NLRP3 inflammasome activation. (2)
The body regulates itself down to its cellular level
via autophagy, the natural process during which the body’s
cells clean out damaged (ie, by inflammation) or unneeded parts. In
a new study, melatonin boosted autophagy
and decreased the degradation of the disc’s
extracellular matrix (technically indicated by a decrease
in marker LC3B, autophagasomes and autolysosomes and inhibition of the NF-kB
signaling pathway). The end conclusion was that melatonin inhibits
intervertebral disc degeneration by promoting autophagy. (3)
Wow. Cox Chiropractic Medicine Inc is encouraged by this research to see just
how well melatonin can perform for Fort Wayne back pain linked
to disc degeneration.
MELATONIN AND ITS HEALING WAYS FOR THE DISC
Disc degeneration is a very common condition
seen at Cox Chiropractic Medicine Inc that positive news of
melatonin’s benefits are quite rousing. A new
study described that melatonin could modify
the extracellular matrix of the disc remodeling process initiated
by IL-1 β. Further, melatonin decreased the
inflammatory cell collection and reduced the release of linked
inflammatory markers IL-1β, IL-6, and TNF-α. With this new discovery
that melatonin disrupted the IL-1B feedback loop, researchers
suggested that melatonin may provide
the restoration process of intervertebral discs after damage has already been done. (1) Cox Chiropractic Medicine Inc will keep
following the new research on the role inflammation performs
in Fort Wayne disc degeneration and melatonin’s role in tackling
INFLAMMATION AND MELATONIN
The significance of melatonin in assisting
to slow or stop painful conditions due to inflammation is increasing.
The description of melatonin as a multitasking molecule influencing
mood, immunity, and energy among other things is quite suitable.
It’s also anti-oxidant, anti-aging, and anti-inflammatory, specifically
by blocking the activation of inflammasomes (4) Melatonin’s
formal chemical name is as about as long as its list of tasks: N-acetyl-5-methoxytryptamine.
The pineal gland produces melatonin naturally. Melatonin influences
the body’s aging, anti-inflammatory, anti-apoptosis (cell death), and autophagy
(cell-cleanout) activities. (1) Melatonin’s specific influence on
inflammation and disc degeneration is most attention-getting
to Cox Chiropractic Medicine Inc and our Fort Wayne back pain patients.
CONTACT Cox Chiropractic Medicine Inc
Listen to this PODCAST
with Dr. Hrefna Sylvia based in Iceland where back pain isn’t much different
from any other country on The Back Doctors Podcast with Dr.
Michael Johnson as she illustrates how The Cox® Technic
System of Spinal Pain Management addresses disc
degeneration for relief of chronic low back pain in her patient.
Schedule your Fort Wayne chiropractic appointment with
Cox Chiropractic Medicine Inc now. We can discuss the role
inflammation plays in your back pain experience and how melatonin may address the related disc